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KMID : 0378619960130010151
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Baptist Hospital Medical Journal
1996 Volume.13 No. 1 p.151 ~ p.158
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Effect of okadaic acid and phorbol ester on the activity of TGF -β-induced a2(I) procollagen promoter
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Abstract
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In order to elucidate the regulation mechanism of collagen gene expression in HEL299 fibroblast. The effects of two well- known chemicals affecting phosphorylation status of the intracellular proteins, okadaic acid (OKA), a protein phosphatase
inhibitor, and phorbol myristate acetate (PMA), a protein kinase C activator, on TGFβ-induced type I collagen synthesis and a2(I) collagen promoter activity of were examined.
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